Certainly weapons / items will have a major impact to everything and I look forward to start seeing them.
After thinking on it a little more my I think I hit some conclusions and here is my thought process:
My first instinct is to say rooms are too big. However it's really tough to say that is an issue because I know theoretically there will be non-combat type rooms to break up the gameplay.
So then I go back to hunting down enemies. In comparing to games that I feel are in spirit of DD, Legend of Zelda series (non-polygonal versions), Diablo, and Binding of Isaac, you are rarely having to chase the enemies. As opposed to when I hit a bat or a slime and then have to run to catch up to it to hit it again.
Then I consider that a major concept of DD is its "pinball" nature. Maybe enemies that have a higher potential to fly away, like bats & slimes, then need to be agressive and come back to you faster. As opposed to ghosts/spiders who I wish would stay the hell away from me
I really do like the bounciness and it will be one of the stand out features. I look forward to the tales of how chain-reactions screwed us over, like having an expoding rat bounce right back into me. I just don't want it to slow down the overall pacing for when those moments aren't happening. Maybe I can't have my cake and eat it too, unless every room is lined with springs? Which sounds terrible and amazing at the same time.